Cocaine Anonymous South Africa

Naltrexone is a prescription medication used to treat alcohol use disorders and opioid use disorders. It helps people stop using these substances and stay away from them.

Naltrexone belongs to a category of medications known as opioid competitors and works by blocking the opioid MU receptor. It blocks the effects of alcohol and opioid medications, preventing the addiction these substances cause. Naltrexone also modifies the way the hypothalamus, pituitary, and adrenal glands (hypothalamic breakdown, HPA axis) interact to inhibit the amount of alcohol consumed.

Naltrexone circulates as an intramuscular injection for long-term release (Vivitrol) and oral tablets. The branded version of naltrexone tablets (Repide) has been discontinued, but a generic publication is available.

Naltrexone tablets were first approved by the U.S. Food and Drug Administration (FDA) in 1984; in 2006, the FDA also approved Vivitrol, a long-term release of naltrexone in intramuscular injection form.

Why is naltrexone used?

Naltrexone is a prescription drug used to

• Treat alcohol dependence
• Rule out the effects of exogenously administered opioids To prevent relapse to opioid dependence after opioid detoxification.

Alcohol drinking and opioid use should be stopped prior to starting naltrexone.

Naltrexone hydrochloride should not be used in children or adolescents under the age of 18.

Naltrexone is a prescription drug used to

• Treat alcohol dependence
• Rule out the effects of exogenously administered opioids To prevent relapse to opioid dependence after opioid detoxification.

Alcohol drinking and opioid use should be stopped prior to starting naltrexone.

Naltrexone hydrochloride should not be used in children or adolescents under the age of 18.

Important Information.

Naltrexone can cause serious side effects, including the following

1. risk of overdosing with opioids.

You can accidentally suffer an overdose in two ways

• Naltrexone blocks the effects of opioid medications. Do not take large doses of opioids, including drugs containing opioids such as heroin or prescription pain relievers, to try to overcome the effects of this opioid drug. This can lead to serious injury, com sleep, or death.
• After receiving a dose of the long-release injectable form of this drug, its inhibitory effects slowly diminish and disappear completely over time. If you have used opioid medications on the road in the past, or if you have used opioid-containing medications, using opioids in the doses used prior to treatment may lead to overdose or death. You may also be more sensitive to the effects of smaller doses of opioids.
  • After detoxification.
  • When giving the next naltrexone infusion
  • When skipping doses of this drug
  • After stopping naltrexone therapy

  It is important to inform your family and those close to you about this increased sensitivity to opioids and the risk of overdose.

  • Has difficulty breathing
  • Delayed breathing and very drowsy
  • You have slow, shallow breathing (small chest movements with breathing)
  • You feel faint, very dizzy, confused or have unusual symptoms

  Discuss with your health care provider naloxone, a drug available to patients for emergency treatment of opioid overdose.

  2. severe reactions to the injection site of naltrexone (reaction to the injection site).

  Some people have had serious reactions to the injection site during naltrexone injections, including tissue death (necrosis). Some of these reactions to the injection site have required surgery. This drug must be administered by injection by a health care provider. Call your health care provider immediately if you notice any of the following at any of the injection points

  • Severe pain
  • Area is difficult to access
  • Large area of swelling
  • Bumps
  • Blisters
  • Open wounds
  • Dark crust

  Update your health care provider of any reactions to the injection site that are worrisome, worsen over time, or do not improve until 2 weeks after injection.

  3. sudden opioid detachment.

  Anyone receiving naltrexone should not use opioids of any kind, including loading medications, prescription pain medications, cough medicines, opioids or opioids, colds or diarrhea, including buprenorphine or methadone treatment. 7-14 days prior to onset of this medication. Use of opioids 7-14 days prior to the onset of treatment may cause sudden opioid deprivation symptoms when receiving treatment. Sudden opioid deprivation can be severe and may require a trip to the hospital.

  You should have been removed from opioids prior to administering naltrexone unless your health care provider first determines that detoxification is not necessary. Instead, your physician may decide to administer this medication to a health care facility that can treat you for sudden opioid deprivation.

  4. liver damage or hepatitis. Naltrexone can cause liver damage or hepatitis.

  Update your health care provider if you have the following symptoms of liver problems during treatment with this drug

  • Pain in the stomach area that lasts more than a few days
  • Dark urine
  • Yellowing of the white eyes
  • Fatigue

  Your health care provider may need to discontinue treatment with this medication if you have signs or symptoms of a serious liver problem.

  You should inform all physicians treating you that you are taking naltrexone. If you need an anesthetic in an emergency, you must use a non-numbing base anesthetic. If you need to use an opiate anesthetic, you may need a higher dose than usual. They may also be more sensitive to side effects (breathing difficulties and circulation problems).

  Who should NOT use naltrexone?

  Do not use naltrexone if you

  • Uses or depends on opioid medications or physical dependence/dependence on opioid medications on the road. To find out if you have a physical dependence on opioids, your health care provider can give you a small injection of a drug called naloxone. This is called a naloxone challenge test. If opioid detachment symptoms occur after the naloxone challenge test, treatment with naltrexone should not be started at that time. The health care provider may repeat the test after stopping opioid use and determining if it is safe to start this medication.
  • Opioid deprivation symptoms. Opioid deprivation opioids can occur when a person stops taking opioids after taking regular opioids. Opioid deprivation symptoms may include
    • Anxiety
    • insomnia
    • absence from work or school
    • fever
    • sweating
    • Tearful eyes
    • runny nose
    • Trembling
    • Shivering
    • Hot flashes from heat or cold
    • Muscle aches
    • muscle contractions
    • Worry
    • Nausea and vomiting
    • Diarrhea
    • Stomach cramps

    What should I tell my doctor before using naltrexone?

    Before receiving naltrexone, notify your health care provider if

    • You have liver problems
    • You use or abuse (illegal) road medications
    • Have hemophilia or other bleeding problems
    • Has kidney problems
    • Has another medical condition
    • Alcohol dependence and use opioids

    How should I use naltrexone?

    Use of opioids 7-14 days prior to starting naltrexone may result in a sudden opioid outbreak. To avoid this, do not use opioids for at least 7-10 days before starting naltrexone therapy.

    How to Take Naltrexone Tablets

    • You should always take this medication as your doctor has told you. If you are not sure, find out from your doctor or pharmacist.
    • Take this medicine as your doctor has told you, one sip a day.
    • Your doctor will determine how long you need to take this medicine. The usual duration of treatment is 3 months. However, in some cases, a longer treatment period may be beneficial.

    How do you receive your Naltrexone injections?

    • Your injection is given by your health care provider approximately once a month.
    • Do not try to inject this medication. You may have a serious reaction, some of which may require inpatient hospitalization.
    • Naltrexone is administered as an injection into the buttock muscle, using a special needle that accompanies the drug.
    • Once the injection is complete, the drug lasts for one month and cannot be removed from the body.

    Whenever you need medical care, inform your treating physician that you are taking this medication and report when you took your last dose. This is important because naltrexone prevents the effects of drugs containing opioids and may be prescribed for pain, cough, colds, or diarrhea.

    Always write down information with you to alert your health care provider that you are taking this medication. Ask your health care provider how to obtain a wallet card.

    What happens if I miss a dose?

    If you miss a dose of naltrexone pills, take it as soon as possible. However, if it is almost time for your next dose, skip the omitted dose and return to your regular dosage program. Do not take a double dose to make up a forgotten dose.

    If you lose an appointment for a naltrexone injection, schedule another appointment as soon as possible.

    What happens if an overdose occurs?

    If you are taking more Naltrexone tablets than you need, tell your doctor or pharmacist or call the nearest emergency department at your hospital immediately.

    What should I avoid while using Naltrexone?

    Do not drive a car, handle machinery, or do any other dangerous activities until you know how this medication affects you. Naltrexone can make you feel dizzy and drowsy.

    Dosing Information

    Tablet:

    • Alcohol dependence: recommended dosage is one tablet (50 mg) once daily.
    • Opioid dependence: start with half a tablet (25 mg) and if no deprivation symptoms occur, increase dosage from there to one tablet (50 mg) per day.

    Intramuscular injection:

    • The recommended dose is 380 mg naltrexone administered as a glute bone injection, alternating every 4 weeks, or alternating with subsequent but parts.

    For more information on Naltrexon dosages, see the complete prescribing information.

    What are the side effects of Naltrexone?

    Serious side effects of Naltrexone include the following

    • See "Important Information" above
    • Depressed mood. Sometimes this leads to suicidal thoughts or suicidal behavior. Tell your family and your people that you are taking this medication. You, your family member, or those closest to you should call your health care provider immediately if you are depressed or have the following symptoms of depression, especially if they are new, worse, or worried
      • You are grieving or crying over the crisis.
      • You are no longer interested in seeing your friends or doing the things you like to do .
      • You sleep much or much less than normal.
      • You feel frantic or helpless.
      • You are more irritable, angry, or aggressive than usual.
      • You are more or less hungry than usual and notice a big change in your weight.
      • You have problems with your attention.
      • You constantly feel tired or sleepy.
      • You have thoughts of harming yourself or ending your life.
      • You have hallucinations.
      • Shortness of breath or wheezing
      • Cough that does not recede
      • Skin rash
      • Swelling of your face, eyes, mouth, or tongue
      • Difficulty breathing or mouth hist
      • chest pain
      • Dizziness or fainting spells

      Frequent side effects of naltrexone include

      • Motion sickness. Nausea may occur when first starting this medication, but can improve with time.
      • vomiting or diarrhea
      • drowsiness
      • Anxiety
      • headache
      • Worry
      • nervousness
      • Abdominal pain
      • Joint pain
      • Muscle aches and muscle cramps
      • Weakness
      • Reduced appetite
      • Heart beat
      • Increased heart rate
      • ECG changes
      • Impaired libido
      • Thirst
      • Dizziness
      • Increased lacrimation
      • chest pain
      • Diarrhea
      • constipation
      • Skin rash
      • Delayed ejaculation and erectile dysfunction
      • Increased energy
      • Irritability
      • Increased sweating
      • Emotional disturbances
      • Cold symptoms
      • Sleep difficulties
      • toothache

      Update your health care provider if you have any side effects that concern you or do not retreat.

      These are not all side effects of this medication. Ask your health care provider or pharmacist for more information.

      For medical advice regarding side effects, contact your physician; you can report side effects to the FDA at 1-800-FDA-1088.

      Interactions

      Tell your health care provider about all medications you are taking, including prescription and over-the-counter medications, vitamins, and herbal supplements.

      In particular, tell your health care provider if you are taking opioid-containing medications for pain, cough, cold, or diarrhea.

      If you are being treated for alcoholism but are using or addicted to opioids or medications containing opioid street drugs, it is important to tell your health care provider before starting naltrexone to avoid sudden opioid withdrawal symptoms at the start of treatment.

      Know what medications you are taking. Keep a list of them and show it to your health care provider and pharmacist when you take new medications.

      Pregnancy and Breastfeeding

      Talk to your doctor if you are pregnant or plan to become pregnant. It is not known whether naltrexone will harm an unborn baby. This medication should be used during pregnancy only if the potential benefits justify the potential risk to the fetus.

      Tell your doctor if you are breastfeeding. It is not known if naltrexone passes into breast milk when injected intravenously, nor is it known if it could harm the baby. Naltrexone from tablets is passed into breast milk. Consult your health care provider about whether to breastfeed or take this medication. You should not do both.

      Storage.

      • Store Naltrexone Tablets at 20° to 25°C.
      • Store the entire box containing Naltrexone Injection in a refrigerator (2°C to 8°C, 36°F to 46°F). Unrefrigerated naltrexone microspheres may be stored at temperatures not exceeding 77 °F (25 °C) for up to 7 days prior to administration. Do not expose unfrozen product to temperatures above 77 °F (25 °C). Do not freeze.

      Keep out of reach of children.

      What are the ingredients in Naltrexone?

      Active ingredients: naltrexone (injection), naltrexone hydrochloride (tablet)

      Vivitrol brand name injection: polylactide-co-glycolide (PLG). Diluting ingredients: sodium carboxymethylcellulose, polysorbate 20, sodium chloride, sodium hydroxide, hydrochloric acid as pH adjuster, water for injection.

      Chartwell: lactose monohydrate, hypomellose, magnesium stearate, polyethylene glycol, titanium dioxide, colloidal dioxide, hydroxypropyl cellulose, yellow oxide, red oxide.

      Inactive ingredients vary among the various generics of naltrexone tablets. For this formulation, check the product label for a complete list of inactive ingredients.

      The Naltrexone Injection brand is prepared and available on the market by Alkermes, Inc. 852 Winter Street, Waltham, MA 02451-1420. Several different companies manufacture and market generic tablets of this drug. Several different companies make and sell common tablets of this drug.

      Popular and Frequently Asked Questions

      Naltrexone blocks the feeling of alcohol intoxication ("buzz") when drinking. This allows people with alcohol problems to reduce their behavior in alcohol consumption, continue treatment, avoid relapse, and take their medications. Over time, cravings for alcohol will decrease. However, naltrexone does not prevent a person from suffering from impairment during alcohol consumption. Do not use naltrexone so that you can drive or perform other activities while under the influence of alcohol. Continue reading

      Low dose naltrexone means taking a dose of naltrexone that is up to 10 percent or 10% of the dose normally taken for opioid addiction. Low dose naltrexone is about 4.5 mg of naltrexone per day, compared to the usual dose of naltrexone for opioid addiction of 50 mg to 100 mg daily. Continue reading

      Do not take opiates, including heroin or other prescription or illegal opiates while using naltrexone. Getting opiates with naltrexone increases the risk of overdose, com sleep, and death. Do not use naltrexone if you are opioid dependent or experiencing opioid deprivation symptoms. Do not use naltrexone before completing medical supervision for opioids that lasts at least 7-14 days. Continue reading

      The manufacturer does not specify whether naltrexone tablets should be taken in the morning or evening. Take naltrexone as directed by your physician. Many patients take their medications in the morning to ensure continued success in treatment for either opioid use disorder or alcohol disorder. Taking naltrexone tablets after meals (for example: breakfast) can help reduce stomach side effects such as nausea and pain. Continue reading

      Weight gain is not a frequent side effect with oral naltrexone therapy. When used in combination with bupropion, naltrexone is approved to promote weight loss. Naltrexone is known to frequently cause gastric side effects, including nausea and vomiting, stomach pain and cramping, and loss of appetite. Weight gain and increased appetite have been reported as possible side effects, but they are not common.

      Alcohol Dependence

      Treat patients who are able to abstain from alcohol in an outdoor clinic prior to starting treatment

      PO: 50 mg once a day for 12 weeks or less

      IM: 380 mg of glut muscle every 4 weeks to maintain abstinence

      Dosage Considerations

      Administer gluteal only as a deep intramuscular injection only

      Hepatitis (orphan)

      Orphanage to treat autoimmune hepatitis

      Sponsor

      • Taiwanj Pharmaceuticals Co., Ltd, Room 204 A, Bldg 53, 195 Chung Hsing Rd., Sec 4, Chutung, Hsinchu, Taiwan.

      Postal Neuralgia (Orphan)

      Characterization of orphans to treat postage neuralgia.

      Sponsor

      • Allodynic Therapeutics, LLC-1785 NE 123rd Street- North Miami, FL 33181-2537

      Security and efficiency not documented

      Crohn's disease (orphan)

      Treatment of pediatric patients

      Sponsor.

      • Jill P. Smith, Penn State University, 500 University Drive, Hershey, PA 17033, Maryland

      Interactions.

      Contraindications.

      Serious - use alternative

      Important - use caution

      Minor.

      Contraindicated (0)

      Serious - use alternative (3)

      • Bremelanotide.

      Bremelanotide decreases naltrexone levels or action by another (see comments). Avoid or use alternative drugs. Bremelanotide may slow down gastric contents and potentially reduce the rate and extent of absorption of oral medications administered at the same time. Avoid the use of bridles with orally administered products that contain naltrexone and are intended to treat alcohol and opioid dependence because of the potential for failure of naltrexone treatment.

      Nardomedin and naltrexone. each of the two increases the impact of the other through pharmacodynamic synergy. Avoid or use alternative medications. Opioid receptor investigation and increased risk of opioid deprivation.

      Nalofugoly, naltrexone. each of the two increases the impact of the other through pharmacodynamic cooperation. Avoid or use alternative medications. Avoid concurrent administration - potential for prosthetic effects on opioid receptors and increased risk of opioid deprivation.

      Monitoring (5)

      • Acamposate.

      Naltrexone increases acamprosate levels through an undetermined interaction mechanism. Use caution/monitoring. No dosage adjustment is necessary.

      Apalutamide decreases naltrexone levels or effects by increasing elimination. Use caution/monitoring. Apalutamide induces UGT and may reduce systemic exposure to drugs that are substrates for UGT.

      Naltrexone enhances the effects of dronabinol on others (see comments). Use caution/monitoring. Comment: naltrexone may enhance the therapeutic effects of cannabinoids.

      Lofexidine reduces naltrexone levels or effects by an unknown mechanism. Modify therapy and monitor closely. Concurrent administration of rofexidine and oral naltrexone produced statistically significant differences in steady-state naltrexone pharmacokinetics. Administration of oral naltrexone within 2 hours of taking rofexidine may reduce the efficacy of oral naltrexone. No interactions with other routes of administration of naltrexone are anticipated.

      Naltrexone enhances the effects of other nabilones (see comments). Precautions for use/monitoring. Comment: naltrexone may enhance the therapeutic effect of cannabinoids.

      Minus (0)

      • Acamposate.

      Monitor with caution (1) Naltrexone increases acamprosate levels by an unspecified interaction mechanism. Precautions for use/monitoring. No dosage adjustment is necessary.

      Monitor Carefully (1) Apalutamide decreases naltrexone levels or effects by increasing depletion. Use caution/monitoring. Apalutamide induces UGT and may reduce systemic exposure to drugs that are substrates for UGT.

      Severe - use alternatives (1) Bremelanotide reduces levels or effects of other naltrexone (see comments). Avoid or use alternatives. Bremelanotide may delay gastric contents evacuation and potentially reduce the rate and extent of absorption of concomitant oral medications. Avoid using bremelanotide with oral naltrexone-containing products intended to treat alcohol and opioid dependence because of the potential for naltrexone treatment failure.

      Monitor carefully (1) Naltrexone enhances the effects of dronabinol and others (see comments); (2) Naltrexone is not a safe and effective treatment for opioid dependence. Caution/monitoring of use. Comment: naltrexone may enhance the therapeutic effects of cannabinoids .

      (1) landexidine reduces naltrexone levels or effects by an unknown mechanism. Close treatment/monitoring changes CO- oral naltrexone with rubexidine produced statistically significant differences in naltrexone pharmacokinetics in a stable state. Dosing within 2 hours of taking rufoxidine reduces the efficacy of oral naltrexone. No interactions with other Naltrexoni delivery routes are anticipated.

      (1) Naltrexone increases the effects of nabilone by others (see comments). Use caution/tracking. Comment: naltrexone can increase the therapeutic effect of cannabinoids.

      Severe - use (1) naltrexone instead of nardomedin, each of the two increases the impact of the other through pharmacodynamic cooperation. Avoid or use alternative medications. Investigate increased risk of opioid receptor prosthesis and opioid deprivation.

      Serious - Use alternative (1) naligolide, naltrexone; one of the two increases the impact of the other through pharmacodynamic cooperation; the other increases the impact of the other through pharmacodynamic cooperation. Avoid or use alternative drugs. Avoid concurrent administration - potential for additional effects of opioid receptor shaking and increased risk of opioid deprivation.

      Unnecessary actions

      Injection site reactions (69% - includes bruising, sclerosis, nodules, pain, itching, edema, sensitivity)

      Decreased appetite (14%)

      Upper respiratory tract infection (URTI) (13%)

      Increased creatine phosphosinase (11%)

      Muscle cramps (8%)

      Increased aspartate aminotransferase (AST) (2%)

      Patient Naltrexone Training by mouth

      Naltrexone HCl-Oral

      Commercial name community name: Revia

      USES: This drug is used to prevent people who are addicted to a particular drug (apiate) from coming back. It is used as part of a complete treatment program for drug abuse (compliance monitoring, counseling, behavioral treaties, lifestyle changes, etc.). This drug should not be used in people who are currently taking opiates, including methadone. This can cause sudden detachment symptoms. Naltrexone belongs to a category of drugs known as opiates competitors. It works in the brain to prevent the effects of opiates (e.g., feeling of wellness, pain relief). It also reduces the desire to take opiates. Ask your doctor or pharmacist if you need to have naloxone available to treat an excessive opioid dose. Inform family and household members about the signs of an opioid overdose and how it is treated. This medication is also used to treat alcohol abuse. It can help people drink less alcohol or stop drinking altogether. It also reduces cravings for alcohol consumption when used in a treatment program that includes counseling, support, and lifestyle changes.

      Instructions for Use: This is a hospital medication: this medication is taken orally with or without food. The usual dose is 50 milligrams once a day or as directed by a physician. This medication can be given as part of a program in which a health care professional sees you take the medicine. In this case, your doctor may order a higher dose (100 to 150 milligrams) every 2 to 3 days to facilitate planning your visits to the clinic. If stomach problems occur, naltrexone can be taken with food or antacids. A urinalysis should be performed to confirm recent opiate use. The physician may offer another medication (naloxone challenge test) to confirm opiate use. Do not use opiates for at least 7 days prior to starting naltrexone. You may need to stop some opiates (such as methadone) 10-14 days before starting naltrexone. Dosage is based on your medical condition and response to treatment. Your doctor may start you on a lower dose and monitor you for any side effects or deprivation symptoms before increasing your dose. Take this medication as directed. Do not increase the dosage. Do not take it frequently. Do not stop taking this medicine without your doctor's approval. Use this medication regularly for maximum benefit. To help you remember, take it at the same time each day. Tell your doctor if you are going to start using drugs or alcohol.

      Side effects: nausea, headache, dizziness, stress, fatigue, and sleep problems may occur. A small number of people may experience mild symptoms of narcotic peeling, including abdominal cramps, anxiety, bone/joint pain, muscle pain, and runny nose. If any of these effects persist or worsen, tell your doctor or pharmacist immediately. Remember that this drug was prescribed because your doctor found that the benefit to you outweighs the risk of side effects. Many people using this medication do not have serious side effects. Within minutes of taking naltrexone, you may experience suspected opiate deprivation symptoms. Tell your doctor immediately if any of these deprivation symptoms occur: abdominal cramps, nausea/vomiting, diarrhea, joint/bone/muscle, mental changes/mood changes (stress, confusion, excessive sleepiness, visual illusions, etc.) nose nose nose. Naltrexone rarely causes severe liver disease. With larger doses, the risk increases. Discuss the risks and benefits with your physician. Discontinue use of this medication and tell your doctor immediately if you develop symptoms. The medication is rare. However, seek medical assistance immediately if you notice symptoms of a severe allergic reaction, such as rash, itching/edema (especially of the face/tongue/throat), severe dizziness, or difficult breathing. This is not a complete list of possible side effects. If you notice any of the other effects listed above, contact your physician or pharmacist. In the United States, call your doctor for medical advice regarding side effects at 1-800-FDA-1088 or www. fda. gov/medwatch. in to notify your doctor about side effects to the FDA. You can report side effects to the FDA at www. fda. gov/medwatch. in. You can report side effects to the Canadian Medical Services at 1-866-234-2345.

      PREPARATION: Before taking naltrexone, tell your doctor or pharmacist if you are allergic or have any other allergies. This product may contain inactive ingredients that may cause allergic reactions or other problems. Consult your pharmacist for more information. Before using this medication, tell your doctor or pharmacist about your medical history, especially any current or recent use (last 7-14 days) of opioid medications of any kind (morphine, methadone , buprenorphine), kidney or liver disease. You should wear a medical identity indicating that you are taking this medication so that appropriate treatment can be given if it is with you or if there is a medical need. This medication can cause dizziness. Alcohol or marijuana (hemp) can cause dizziness. Do not drive, use machinery, or do anything that requires alerting until you can safely do so. Avoid alcoholic beverages. Consult a physician if you use marijuana (cannabis). After discontinuation of naltrexone treatment, become more sensitive to low doses of opioids, which may increase the risk of potentially life-threatening adverse effects than opioids (e.g., decreased loss of breath awareness). This drug prevents the effects of opiate drugs (including heroin) and similar drugs (opioids). However, large amounts of heroin or opioids can overcome this blockade. Attempts to overcome this exclusion are extremely dangerous and can cause serious injury, loss of consciousness, and death. Be sure to fully understand and accept the risks and benefits of using this medication. Follow your doctor's instructions. Inform your physician or dentist that you are taking this medication before undergoing surgery or treatment. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your physician. This medication passes breast milk. Consult your physician before breastfeeding.

      Drug Interactions: Drug interactions can alter the way a drug works or increase the risk of serious side effects. This document does not include all possible drug interactions. Keep a list of all products you use (including prescription/non-prescription drugs and botanical products) and share it with your physician or pharmacist. Do not start, stop, or change the dosage of any medication without a physician's approval. (hydrocodone), thioridazine. This drug can affect certain laboratory tests (including drug tests) and potentially cause false test results. Make sure that laboratory staff and all physicians know that you are using this drug.

      OVERDOSE: If someone overdoses and has severe symptoms such as fainting or difficulty breathing, call 166. U.S. residents can call their local poison control center at 1-800-222-1222. Canadian residents can call their provincial poison control center at 1-800-222-1222.

      NOTE: Do not share this medication with others. You should have laboratory and/or medical tests (such as liver function) done while taking this medication. You will keep all medical and laboratory appointments. Consult your physician for more information.

      Brand Dos: Remember, if you skip a dose as soon as you take it. If you are close to the next dose, skip the omitted dose. Take the next dose at the normal time. Do not double the dose to prevent

      STORAGE: Store at room temperature away from light and humidity. Do not store product in bathrooms. Keep all medications away from children and pets. Do not throw medications down the toilet. Do not throw into sewage unless instructions are given. Properly dispose of this product when it has expired or is no longer needed. Consult your pharmacist or local waste disposal company.

      Information last revised November 2022. Copyright (c) 2023 First Databank, Inc.

      IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does not have all possible information about this product. This information is not intended to guarantee that this product is safe, effective or appropriate. This information does not constitute individualized medical advice and is not intended to replace the advice of a health care professional. Always ask your health care professional for complete information about this product and your specific health needs.